cGAS Ab
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cGAS Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
cGAS Ab
Immunohistochemical analysis of paraffin-embedded Human Cholangiocarcinoma, using the Antibody at 1:100 dilution.
cGAS Ab
Immunohistochemical analysis of paraffin-embedded Human Tonsil tissue, using the Antibody at 1:100 dilution.
cGAS Ab
cGAS Ab
cGAS Ab
cGAS Ab
cGAS Ab
cGAS Ab
cGAS Ab
cGAS Ab
cGAS Ab

产品简介

Product Introduction

Catalog No.

CY8930

Source

Recombinant Rabbit mAb

UniProt ID

Q8N884

Reactivity

Human

Application

WB;IHC

Calculated Mol Weight

59 kDa

Observed Mol Weight

62 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

Alternative Names

h-cGAS; C6orf150; MB21D1; cGAMP synthase; Cyclic GMP-AMP synthase;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human cGAS

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production.

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CY8930

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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